Optimized Regulation of Gene Expression Using Artificial Transcription Factors
نویسندگان
چکیده
منابع مشابه
Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs.
Epigenetic silencing of tumor suppressor genes (TSGs) is considered a significant event in the progression of cancer. For example, EPB41L3, a potential biomarker in cervical cancer, is often silenced by cancer-specific promoter methylation. Artificial transcription factors (ATFs) are unique tools to re-express such silenced TSGs to functional levels; however, the induced effects are considered ...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2002
ISSN: 1525-0016
DOI: 10.1006/mthe.2002.0610